Arsenic ... Cadmium ... Lead ... Mercury
Agency for Toxic Substances and Disease Registry
For most people, food constitutes the largest source of arsenic intake (about 25 to 50 micrograms per day--a microgram is one millionth of a gram), with lower amounts coming from drinking water and air. Some edible fish and shellfish contain elevated levels of arsenic, but this is predominantly in an organic form ("fish arsenic") that has low toxicity. Above-average levels of exposure are usually associated with one or more of the following situations ... Natural mineral deposits in some geographic areas ... Some waste-chemical disposal sites contain large quantities of arsenic ... Low levels of arsenic are found in most fossil fuels (oil, coal, gasoline, and wood) ... The main use of arsenic in this country is for pesticides ... Arsenic enters the body principally through the mouth, either in food or in water ... poison ... exposure may produce injury in a number of different body tissues irritation of the digestive tract, leading to pain, nausea, vomiting, and diarrhea ... decreased production of red and white blood cells, abnormal heart function, blood vessel damage, liver and/or kidney injury, and impaired nerve function causing a "pins-and-needles" ... Perhaps the single most characteristic systemic effect of oral exposure to inorganic arsenic is a pattern of skin abnormalities including the appearance of dark and light spots on the skin, and small "corns" on the palms, soles, and trunk ... increase the risk of cancer inside the body, especially in the liver, bladder, kidney, and lung ... Measuring the levels of arsenic in urine is the best way to determine exposures that occurred within the last 1 to 2 days ... Studies in humans indicate that there is considerable variation among different individuals, and it is difficult to identify with certainty the exposure ranges of concern ...
Arsenic and Barium ITER Peer Review Meeting Summary
June 14 and 15, 1999; University of Cincinnati, College of Medicine
epidemiological data adequate ... associated with structural malformations ... No, the existing epidemiological data are not adequate ... The review panel agreed to replace the term "teratogenic effects" with the word "malformations." ... The panel unanimously agreed that no, sodium arsenate, sodium arsenite, arsenic trioxide, and arsenic acid do not induce malformations in animals when administered orally. These forms of inorganic arsenic have been tested in several species of experimental animals ...
Arsenic Trioxide, Hazardous substance fact sheet
New Jersey Department of Health and Senior Services
Arsenic Trioxide can affect you when breathed ... Arsenic Trioxide is a CARNICOGEN ...
U.S. EPA IRIS, April 10, 1998
Sufficient. Studies of smelter worker populations ... have all found an association between occupational arsenic exposure and lung cancer mortality ... A cross-sectional study of 40,000 Taiwanese exposed to arsenic in drinking water found significant excess skin ... incidence of palmar keratosis, skin hyperpigmentation and hypopigmentation, and four skin cancers ... A significant dose-response relationship was found between arsenic levels in artesian well water in 42 villages in the southwestern Taiwan and age- adjusted mortality rates from cancers at all sites ...
Arsenic and Compounds
United States Environmental Protection Agency, 2000
Other sources of inorganic arsenic exposure include burning plywood treated with an arsenic wood preservative or dermal contact with wood treated with arsenic ... Reproductive/Developmental Effects: Several studies suggest that women who work in, or live near, metal smelters may have higher than normal spontaneous abortion rates, and their children may exhibit lower than normal birthweights. However, these studies are limited ... studies have reported inorganic arsenic exposure to be strongly associated with lung cancer ...
Qué es arsenic trioxide?: Arsenic trioxide es un medicamento contra el cáncer. Arsenic trioxide interfiere con el crecimiento de las células cancerosas y demora su crecimiento y distribución por el cuerpo.
Arsenic trioxide se usa en el tratamiento de leucemia promielocítica aguda (LPA/APL).
Arsenic trioxide puede también ser usada para fines diferentes a los mencionados en esta guía del medicamento.
Last Updated: 2008/3/10