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Prozac (Fluoxetine) in Pregnancy by OTIS
"... The information below will help you determine if Prozac represents an increased fetal risk. If you have any additional questions or for more information regarding OTIS, contact the Teratology Information Service in your area ... with every pregnancy, all women have a 3 to 5 percent chance to have a baby with a birth defect ... Prozac is a medication commonly used to treat obsessive compulsive disorders and eating disorders (bulimia nervosa). The generic name of Prozac is fluoxetine ... each individual's ability to break down the medication is different ... There are reports of over 1,000 pregnancies exposed to Prozac during the first trimester. No study found an increased risk for major structural birth defects (those requiring surgery or reducing function). One study has identified an increased rate of three or more minor birth defects (those not medically or functionally significant) among children exposed to Prozac in the first trimester. When three or more minor birth defects are seen together, a major birth defect (including learning problems) occurs more often, although this was not seen in the Prozac study ... studies have begun to look at the possible long-term effects on infants exposed to Prozac during pregnancy ..."

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IBIS:International Birth Defects Information Systems

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21/January/2002 dc